Ribonucleoside-5′-diphosphates (NDPs) support RNA polymerase transcription, suggesting NDPs may have been substrates for primordial nucleic acid biosynthesis
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چکیده
منابع مشابه
Evaluation of Nucleic Acid Sequence Based Amplification (NASBA) and Reverse Transcription Polymerase Chain Reaction for Detection of Coxsackievirus B3 in Cell Culture and Animal Tissue Samples
Enteroviruses are the causative agents of a number of diseases in humans. Group B coxsackieviruses are believed to be the most common viral agents responsible for human heart disease. Genomic data of enteroviruses has allowed developing new molecular approaches such as Nucleic Acid Sequence Based Amplification (NASBA) for detection of such viruses. In this study, coxsackievirus B3 (CVB3) was de...
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Spt4/5 in archaea and eukaryote and its bacterial homolog NusG is the only elongation factor conserved in all three domains of life and plays many key roles in cotranscriptional regulation and in recruiting other factors to the elongating RNA polymerase. Here, we present the crystal structure of Spt4/5 as well as the structure of RNA polymerase-Spt4/5 complex using cryoelectron microscopy recon...
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N-(3,5-Dichlorophenyl)succinimide (NDPS) was originally developed as an agricultural fungicide. Previous work indicated that NDPS-induced renal damage in rats is metabolism-dependent and that hydroxylated metabolites might be involved in the nephrotoxic response. In this study, the disposition and nephrotoxicity of [14C]NDPS at two time points (3 and 24 hr) and three doses (0.2, 0.4, and 0.6 mm...
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The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) produces kidney damage in rats. Although many NDPS analogues have been screened as possible nephrotoxicants, the one-carbon homologue, N-(3,5-dichlorophenyl)glutarimide (NDPG), has not been evaluated. This study examined the nephrotoxic potential of NDPG and a putative metabolite, N-(3,5-dichlorophenyl)glutaramic acid (NDPGA). ...
متن کامل-Agents that interfere with Nucleic Acid Biosynthesis
I. Sulfonamides the oldest class of antibiotics A) Structures 1) History It is appropriate to give a brief description of the history of the sulfonamides, as they were the first antibiotics developed. Scientists at Bayer in Germany discovered in the early 1930’s that protonsil rubrum, a red dye, would block infections in laboratory animals. Surprisingly, this compound did not block infections i...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2019
ISSN: 0021-9258
DOI: 10.1074/jbc.ra119.009074